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DNA Microrrayer System
  • Overview
  • Quick View Leaflet
  • Technical Brochure
  • Application Procedure

DNA Microrrayer System

Overview

DNA micro array technology is a powerful tool emerging in the field of functional genomics. The DNA Microarrayer is a very precise computer controlled 3-axis robotics system for making DNA microarrays to find out the expression levels of large number of genes simultaneously and genetic disorder in clinical diagnostic. The most challenging task is to print large number of DNA samples of all sequences at a very small area in few nano-litres quantities with micron level positional accuracy. The design of precise robotic system and its software for automation of the process has helped in achieving and maintaining desired level of accuracy needed for the system along with user friendly features.

DNA Microrrayer System

DNA Microrrayer System

 

Quick View Leaflet

The Microarrayer is a very precise computer controlled 3-axes robotics system to deposit high-density, gridded arrays of genomic DNA or similar biological materials at discrete locations in microscopic quantities. Such a capability permits for all possible genes that can be expressed in a given organism in a two-dimensional array at a high-density on a solid surface for high throughput analysis. These targets are then hybridized with fluorescence labeled complimentary sequences in a test sample (DNA or RNA). It is the first indigenously developed system in BARC and promises to make mutation detection, gene expression analysis and disease diagnosis in less time and is more efficient, thus revolutionizing in area of biotechnology and medicine.

FEATURES

  • Servomotors & high resolution encoders for X , Y & Z axes

  • Liquid handling by capillary action

  • Micron level accuracy

  • Contact printing

  • Precise robotic system for automation

  • Computer for control & data display

SOFTWARE FEATURES INCLUDE

  • A Procedure creation wizard and automatic procedure validation

  • Custom microarray designs

  • Customizable Wash/Dry protocols

  • Complete Sample tracking

APPLICATIONS

  • Gene expression analysis in medicine and agriculture

  • Disease diagnosis (Large scale genetic variation )

  • High throughput mutation detection

DNA Microrrayer System

Technical Brochure

The Microarrayer is a very precise computer controlled 3-axes robotics system to deposit high-density, gridded arrays of genomic DNA or similar biological materials at discrete locations in microscopic quantities. The robotic system based on servo motors with high-resolution encoders & advanced control scheme, well damped table and unique pin tip assembly to provide better positional accuracy of few micron, higher throughput and user friendly control software to define all critical parameters for printing operation. Both hardware and software are designed to provide high performance automation together with the flexibility required for individual sample handling and custom designed. The robot is designed to collect samples automatically from the wells of either a 96 or a 384-well micro-titre plate with up to 32 specially made pins by capillary action and deposits approximately 1 nano-litre on each slide.

DNA Microrrayer System

FEATURES

  • Servomotors, precise linear guides & high resolution encoders for X , Y & Z axes
  • Micron level accuracy of biological sample spot
  • Precise robotics system for automation
  • Liquid handling by capillary action
  • Vacuum chamber and cleaner for drying and cleaning of pins
  • Hardware and software interlocks
  • Computer for control & data display

SOFTWARE FEATURES INCLUDE

  • A Procedure creation wizard and automatic procedure validation
  • Custom microarray designs
  • Customizable Wash/Dry protocols
  • Complete Sample tracking

SPECIFICATIONS

Positional repeatability : 10 micron
Liquid handling / delivery (Capillary) : ~1 nano-litre – 1 pico-litre per spot
Printing density : 7000 per slide
Printing type : Contact printing
Slide handling capacity : Up to 40 slides
Spot Diameter : < 300 microns
Dimensions : 72 x 70 x 120 cm (W x D x H)
Weight : 70 kg
Maximum Well Plates : 2
Pin Holder capacity : 32 Pins

APPLICATIONS

  • Gene expression analysis
  • Disease diagnosis (Large scale genetic variation )
  • High throughput mutation detection

INFRASTRUCTUAL REQUIREMENT

a. Space

  • This system is a standalone system and requires a dedicated floor space of 75 cm x 75 cm.
  • b. Manpower

    • One Electronics or Electrical engineer for control system, hardware manufacturing, assembling, testing the system.
    • One software engineer for software development, maintenance of control software of DNA Microarrayer system.

    c. Power Supply

    • Mains Voltage : 240 V
    • Mains Fuse : 5 A
    • Power Consumption : 300 W
    • Operating Temperature : 0° C to 30° C
    • Operating Humidity : 0 - 80% non-condensing

    TEST EQUIPMENTS

    • Standard test and measuring facility for instruments like Oscilloscope, DVM, Multimeter, Soldering machine, Co-ordinate measuring machine, Dial gauge etc.

    OTHER FACILITIES

    • Manufacturing facility with CNC machines

    Who Should apply


    Interested parties with Engineering & Scientific knowledge, good financial background and adequate experience of products manufacturing & fabrication with technical capability in the area of interested technology and having or interested in setting –up facilities for production would be preferred.


    How to apply

    Send your Technology Transfer Application form duly filled and signed alongwith a Demand Draft/Bankers cheque of Rs. 500/- (for Indian entities) or US $50/- (for foreign entities) drawn in favour of “Accounts Officer, BARC” as application processing fee on following address: 

    Head, Technology Transfer and Collaboration Division 
    Bhabha Atomic Research Centre,
    Trombay, Mumbai – 400 085, India.

    Fax : +91-22-25505151


    Note:Applications without processing fee as applicable above of Rs. 500/- or US $50/- for each technology will not be considered.


    Click here for Technology Transfer Application Form

    Contact Us

    Head, 
    Technology Transfer and Collaboration Division
    Bhabha Atomic Research Centre,
    Trombay, Mumbai 400 085.

    Fax : 091-022- 25505151
    Email : technology@barc.gov.in

    How to apply

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